中文名 | 3-IODOBENZYL-GUANIDINE HEMISULFATE |
英文名 | 3-IODOBENZYL-GUANIDINE HEMISULFATE |
别名 | 硫酸碘苄胍 EP标准品 1-(3-碘苄基)胍半硫酸盐 |
英文别名 | M-IBG MIBG hemisulfate MIBG HEMISULFATE SALT IOBENGUANE HEMISULFATE m-iodobenzylguanidine sulfate 3-IODOBENZYL-GUANIDINE HEMISULFATE meta-Iodobenzylguanidine hemisulfate M-IODOBENZYLGUANIDINE HEMISULFATE SALT |
CAS | 87862-25-7 |
化学式 | C16H22I2N6O4S |
分子量 | 648.26 |
存储条件 | 2-8°C |
体外研究 | Iobenguane sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines. Iobenguane sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range. Cell Proliferation Assay Cell Line: 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells Concentration: 2, 20μg/ml Incubation Time: 72 hours Result: Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth. |
体内研究 | Iobenguane sulfate (MIBG hemisulfate) (20 mg/kg; i.p.; daily on days 3-6) shows antitumor activity. The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed. Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg. Animal Model: DBA/2 (L1210)) mice Dosage: i.p.; daily on days 3-6 Administration: 20 mg/kg Result: Considerable prolongation of survival and some cures were obtained. |
WGK Germany | 3 |
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